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This page presents the lecture notes for each class session, plus supporting multimedia for some sessions.
Lecture notes files.
| LEC # |
TOPICS |
SUPPORTING MULTIMEDIA |
| 1 |
Introduction to nanomechanics (PDF) |
Feynman, Richard. Tiny Machines. Audio CD, Sound Photosynthesis, 1984. |
| 2 |
High resolution force spectroscopy (HRFS): The force transducer (PDF) |
|
| 3 |
Additional nanomechanics instrumentation components (PDF) |
|
| 4 |
Force versus distance curves (PDF) |
|
| 5 |
Atomic force microscope (AFM) imaging (PDF) |
Video: "Understanding AFM"
(RM - 56K)
(RM - 220K) (MOV - 111.5MB)
(Courtesy of Asylum Research, Inc. Used with permission)
Force curve animation, from NC State University (MOV)
|
| 6 |
AFM imaging II: Artifacts and applications (PDF) |
|
| 7 |
Single cell mechanics (PDF) |
|
| 8 |
Qualitative Introduction to intra- and intermolecular forces (PDF) |
Protein Folding demo [You will need the MDL Chime plugin for your browser, which is a free download.] |
| 9 |
Quantitative description of intra- and intermolecular forces (PDF) |
|
| 10 |
Molecule-surface interactions (PDF) |
|
| 11 |
Colloids and interparticle potentials (PDF) |
|
| 12 |
Van der Waals forces at work: Gecko feet adhesion (PDF) |
|
| 13 |
Midterm exam solutions review (PDF) |
|
| 14 |
The electrical double layer (EDL) - part 1 (PDF) |
|
| 15 |
The electrical double layer (EDL) - part 2 (PDF) |
|
| 16 |
Nanomechanics of cartilage (PDF - 2.0 MB) |
|
| 17 |
Protein-surface interactions (PDF - 1.3 MB) |
Polymer Brush simulation. John Marko, Cornell University, 1994.
Simulation of Polymer Brush Interacting with Nanosized Object (AVI) (Courtesy of Jan Hoh. Used with permission.)
|
| 18 |
Nanomechanics and biocompatibility: Protein-biomaterial interactions, part 2 (PDF) |
Same as prior session. |
| 19 |
Elasticity of single polymer chains: Theoretical formulations (PDF) |
|
| 20 |
Theoretical aspects of single molecule force spectroscopy: Extensibility and the worm-like chain (WLC) (PDF) |
|
| 21 |
Single chain elasticity of biomacromolecules: The giant protein titin and DNA (PDF) |
From the Theoretical and Computational Physics Group, UIUC:
Movie of SMFS Fibronectin stretching (MPEG - 1.7 MB)
Simulations of unfolding titin immunoglobulin domains
|
| 22 |
Theoretical aspects of nanoindentation (PDF) |
|
| 23 |
Nanoindentation 2: Oliver-Pharr method and one literature example: Nacre (PDF - 1.0 MB) |
|
| 24 |
Intermolecular interactions in motility of a biological spring (guest lecture by Danielle France, course TA) |
|