New courses in Biology http://ocw.mit.edu/OcwWeb/Biology/index.htm 2008-01-18 MIT OpenCourseWare http://ocw.mit.edu en-US Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/OcwWeb/web/terms/terms/index.htm Biology of cells of higher organisms: structure, function, and biosynthesis of cellular membranes and organelles; cell growth and oncogenic transformation; transport, receptors and cell signaling; the cytoskeleton, the extracellular matrix, and cell movements; chromatin structure and RNA synthesis. http://ocw.mit.edu/OcwWeb/Biology/7-06Spring-2007/CourseHome/index.htm Orr-Weaver, Terry Ploegh, Hidde L. 2007-09-28T12:04:36-04:00 7.06 en-US Biology Molecular Genetics Cell/Cellular Biology and Histology RNA synthesis RNA chromatin cell movements matrix extracellular matrix cytoskeleton cell signaling receptors transport oncogenic transformation cell growth organelles cellular membranes biosynthesis organisms cells MIT Open Course Ware http://ocw.mit.edu Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/OcwWeb/web/terms/terms/index.htm Seminar covering topics of current interest in biology. Includes reading and analysis of research papers and student presentations. Contact Biology Education Office for topics. From the course home page: Course Description The main goal of this seminar will be to study the nervous system from the perspective of neuron-glia interactions. In each class, we will focus on one type of glial cell and discuss its origin, classification and function within the nervous system. Current findings concerning diseases associated with each type of glial cell will be discussed. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. Many instructors of the Advanced Undergraduate Seminars are postdoctoral scientists with a strong interest in teaching. http://ocw.mit.edu/OcwWeb/Biology/7-343Spring-2007/CourseHome/index.htm Akten, Bikem 2007-09-18T09:27:15-04:00 7.343 en-US Biology Cell/Cellular and Molecular Biology Gliomas demyelination CNS Astrocytes schizophrenia Neuregulin-1 Nogo Hypothesis Oligodendrocytes connexin-32 gene Charcot-Marie-Tooth (CMTX) disease Nodes of Ranvier Schwann cells Myelination neurodegeneration brain damage epilepsy Alzheimer’s Disease HIV-associated dementia glioblastoma multiforme Multiple Sclerosis nervous system synapse control synapse formation neurons nervous system Rudolph Virchow glial cell glial MIT Open Course Ware http://ocw.mit.edu Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/OcwWeb/web/terms/terms/index.htm Seminar covering topics of current interest in biology. Includes reading and analysis of research papers and student presentations. Contact Biology Education Office for topics. From the course home page: Course Description How do we communicate with the outside world? How are our senses of vision, smell, taste and pain controlled at the cellular and molecular levels? What causes medical conditions like allergies, hypertension, depression, obesity and various central nervous system disorders? G-protein coupled receptors (GPCRs) provide a major part of the answer to all of these questions. GPCRs constitute the largest family of cell-surface receptors and in humans are encoded by more than 1,000 genes. GPCRs convert extracellular messages into intracellular responses and are involved in essentially all physiological processes. GPCR dysfunction results in numerous human disorders, and over 50% of all prescription drugs on the market today directly or indirectly target GPCRs. In this course, we will discuss GPCR signal transduction pathways, GPCR oligomerization and the diseases caused by GPCR dysfunction. We will study the structure and function of rhodopsin, a dim-light photoreceptor and a well-studied GPCR that converts light into electric impulses sent to the brain and leads to vision. We will also discuss how mutations in rhodopsin cause retinal degeneration and congenital night blindness. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. Many instructors of the Advanced Undergraduate Seminars are postdoctoral scientists with a strong interest in teaching. http://ocw.mit.edu/OcwWeb/Biology/7-342Spring-2007/CourseHome/index.htm Kota, Parvathi 2007-09-10T04:55:17-04:00 7.342 en-US Biology Oncology and Cancer Biology Taste receptors Olfactory receptors CCR5-delta32 HIV-1 CCR5 Human chemokine receptor 5 Claviceps purpurea antihistamines Dopamine night blindness retinitis pigmentosa heterodimers homodimers metarhodopsin II transducin chromophore vision George Wald cell-surface receptors GPCR G-protein coupled receptors central nervous system disorders obesity depression hypertension allergies MIT Open Course Ware http://ocw.mit.edu Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/OcwWeb/web/terms/terms/index.htm This course explores the specific ways by which microbes defeat our immune system and the molecular mechanisms that are under attack (phagocytosis, the ubiquitin/proteasome pathway, MHC I/II antigen presentation). Through our discussion and dissection of the primary research literature, we will explore aspects of host-pathogen interactions. We will particularly emphasize the experimental techniques used in the field and how to read and understand research data. Technological advances in the fight against microbes will also be discussed, with specific examples. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. Many instructors of the Advanced Undergraduate Seminars are postdoctoral scientists with a strong interest in teaching. http://ocw.mit.edu/OcwWeb/Biology/7-340Spring-2007/CourseHome/index.htm Grotenbreg, Gijsbert Paquet, Marie-Eve 2007-08-07T01:42:44-04:00 7.340 en-US Biology Immunology Burkitt’s B cell lymphoma EBV Epstein Barr virus Mixoma virus Kaposi Sarcoma-Associated Herpes virus AIDS Histocompatiblity HCMV Human cytomegalovirus viral budding Yersinia HSV Herpes simplex virus DUB deubiquinating enzymes Ubiquitin Proteasome Vaccinia virus TLR Toll-like receptors PAMP pathogen-associated molecular patterns Salmonella MHC I/II antigen presentation ubiquitin/proteasome pathway phagocytosis microbes parasites bacteria viruses pathogens immune system influenza malaria mycobacterium tuberculosis HIV MIT Open Course Ware http://ocw.mit.edu Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/OcwWeb/web/terms/terms/index.htm Seminar covering topics of current interest in biology. Includes reading and analysis of research papers and student presentations. Contact Biology Education Office for topics. From the course home page: Course Description The lethal poison Ricin (best known as a weapon of bioterrorism), Diphtheria toxin (the causative agent of a highly contagious bacterial disease), and the widely used antibiotic tetracycline have one thing in common: They specifically target the cell's translational apparatus and disrupt protein synthesis. In this course, we will explore the mechanisms of action of toxins and antibiotics, their roles in everyday medicine, and the emergence and spread of drug resistance. We will also discuss the identification of new drug targets and how we can manipulate the protein synthesis machinery to provide powerful tools for protein engineering and potential new treatments for patients with devastating diseases, such as cystic fibrosis and muscular dystrophy. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. Many instructors of the Advanced Undergraduate Seminars are postdoctoral scientists with a strong interest in teaching. http://ocw.mit.edu/OcwWeb/Biology/7-344Spring-2007/CourseHome/index.htm Sassanfar, Mandana Koehrer, Caroline 2007-08-30T08:40:12-04:00 7.344 en-US Biology Toxicology Aminoglycoside Chloramphenicol Pseudomonas exotoxin A Diphtheria toxin Shiga eukaryotes prokaryotes E. coli ribosome genetic code translation factors tRNA mRNA rRNA ribosomal proteins ribosome muscular dystrophy cystic fibrosis protein engineering drug resistance protein synthesis tetracycline contagious bacterial disease Diphtheria Ricin lethal poison MIT Open Course Ware http://ocw.mit.edu Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/OcwWeb/web/terms/terms/index.htm